Angiotensin-(1-7) counteracts Angiotensin II-induced senescence in telomerase-immortalized human mesenchymal stem cells.
Marmara Medical Journal
PubMed / DOI ↗Scientific Publications
Cardiac toxicity of PAMAM dendrimer drug delivery systems can be attenuated with the adjunct use of cardioprotective agents.
Biomolecules and Biomedicine
PubMed / DOI ↗Targeting the epidermal growth factor receptor (EGFR/ErbB) for the potential treatment of renal pathologies.
Frontiers in pharmacology
PubMed / DOI ↗The Role of Epidermal Growth Factor Receptor Family of Receptor Tyrosine Kinases in Mediating Diabetes-Induced Cardiovascular Complications.
Frontiers in pharmacology
PubMed / DOI ↗Emerging innate biological properties of nano-drug delivery systems: A focus on PAMAM dendrimers and their clinical potential.
Advanced drug delivery reviews
PubMed / DOI ↗Pharmacotherapy in COVID-19 patients: a review of ACE2-raising drugs and their clinical safety.
Journal of drug targeting
PubMed / DOI ↗Nanotoxicology of Dendrimers in the Mammalian Heart: ex vivo and in vivo Administration of G6 PAMAM Nanoparticles Impairs Recovery of Cardiac Function Following Ischemia-Reperfusion Injury.
International journal of nanomedicine
PubMed / DOI ↗Ang-(1-7)/ MAS1 receptor axis inhibits allergic airway inflammation via blockade of Src-mediated EGFR transactivation in a murine model of asthma.
PloS one
PubMed / DOI ↗Chronic administration of nano-sized PAMAM dendrimers in vivo inhibits EGFR-ERK1/2-ROCK signaling pathway and attenuates diabetes-induced vascular remodeling and dysfunction.
Nanomedicine : nanotechnology, biology, and medicine
PubMed / DOI ↗Src-dependent EGFR transactivation regulates lung inflammation via downstream signaling involving ERK1/2, PI3K?/Akt and NF?B induction in a murine asthma model.
Scientific reports
PubMed / DOI ↗Angiotensin-(1-7) Downregulates Diabetes-Induced cGMP Phosphodiesterase Activation in Rat Corpus Cavernosum.
BioMed research international
PubMed / DOI ↗Angiotensin-(1-7)-dependent vasorelaxation of the renal artery exhibits unique angiotensin and bradykinin receptor selectivity.
Peptides
PubMed / DOI ↗Impact of PAMAM delivery systems on signal transduction pathways in vivo: Modulation of ERK1/2 and p38 MAP kinase signaling in the normal and diabetic kidney.
International journal of pharmaceutics
PubMed / DOI ↗Naked Polyamidoamine Polymers Intrinsically Inhibit Angiotensin II-Mediated EGFR and ErbB2 Transactivation in a Dendrimer Generation- and Surface Chemistry-Dependent Manner.
Molecular pharmaceutics
PubMed / DOI ↗Endogenous angiotensin-(1-7)/Mas receptor/NO pathway mediates the cardioprotective effects of pacing postconditioning.
American journal of physiology. Heart and circulatory physiology
PubMed / DOI ↗Transactivation of ErbB Family of Receptor Tyrosine Kinases Is Inhibited by Angiotensin-(1-7) via Its Mas Receptor.
PloS one
PubMed / DOI ↗Cationic Polyamidoamine Dendrimers as Modulators of EGFR Signaling In Vitro and In Vivo.
PloS one
PubMed / DOI ↗The dual targeting of EGFR and ErbB2 with the inhibitor Lapatinib corrects high glucose-induced apoptosis and vascular dysfunction by opposing multiple diabetes-induced signaling changes.
Journal of drug targeting
PubMed / DOI ↗Chronic treatment with Ang-(1-7) reverses abnormal reactivity in the corpus cavernosum and normalizes diabetes-induced changes in the protein levels of ACE, ACE2, ROCK1, ROCK2 and omega-hydroxylase in a rat model of type 1 diabetes.
Journal of diabetes research
PubMed / DOI ↗RU28318, an aldosterone antagonist, in combination with an ACE inhibitor and angiotensin receptor blocker attenuates cardiac dysfunction in diabetes.
Journal of diabetes research
PubMed / DOI ↗Activation of ErbB2 and Downstream Signalling via Rho Kinases and ERK1/2 Contributes to Diabetes-Induced Vascular Dysfunction.
PloS one
PubMed / DOI ↗The role of epidermal growth factor receptor in diabetes-induced cardiac dysfunction.
BioImpacts : BI
PubMed / DOI ↗Role of angiotensin II and angiotensin-(1-7) in diabetes-induced oxidative DNA damage in the corpus cavernosum.
Fertility and sterility
PubMed / DOI ↗On the nanotoxicity of PAMAM dendrimers: Superfect® stimulates the EGFR-ERK1/2 signal transduction pathway via an oxidative stress-dependent mechanism in HEK 293 cells.
International journal of pharmaceutics
PubMed / DOI ↗Chronic treatment with LY294002, an inhibitor of phosphatidylinositol 3-kinase, attenuates ischemia/reperfusion-induced cardiac dysfunction in normotensive and hypertensive diabetic animals.
Molecular and cellular biochemistry
PubMed / DOI ↗Activation of EGFR/ERBB2 via pathways involving ERK1/2, P38 MAPK, AKT and FOXO enhances recovery of diabetic hearts from ischemia-reperfusion injury.
PloS one
PubMed / DOI ↗Angiotensin-(1-7) via the mas receptor alleviates the diabetes-induced decrease in GFAP and GAP-43 immunoreactivity with concomitant reduction in the COX-2 in hippocampal formation: an immunohistochemical study.
Cellular and molecular neurobiology
PubMed / DOI ↗Characterization of Angiotensin-(1-7) effects on the cardiovascular system in an experimental model of type-1 diabetes.
Pharmacological research
PubMed / DOI ↗Angiotensin-(1-7) inhibits allergic inflammation, via the MAS1 receptor, through suppression of ERK1/2- and NF-?B-dependent pathways.
British journal of pharmacology
PubMed / DOI ↗Angiotensin-(1-7) inhibits epidermal growth factor receptor transactivation via a Mas receptor-dependent pathway.
British journal of pharmacology
PubMed / DOI ↗Inhibition of Ras-GTPase farnesylation and the ubiquitin-proteasome system or treatment with angiotensin-(1-7) attenuates spinal cord injury-induced cardiac dysfunction.
Journal of neurotrauma
PubMed / DOI ↗Effect of inhibition of the ubiquitin-proteasome-system and I?B kinase on airway inflammation and hyperresponsiveness in a murine model of asthma.
International journal of immunopathology and pharmacology
PubMed / DOI ↗Angiotensin-(1-7) blockade attenuates captopril- or hydralazine-induced cardiovascular protection in spontaneously hypertensive rats treated with NG-nitro-L-arginine methyl ester.
Journal of cardiovascular pharmacology
PubMed / DOI ↗Role of 20-hydroxyeicosatetraenoic and epoxyeicosatrienoic acids in the regulation of vascular function in a model of hypertension and endothelial dysfunction.
Pharmacology
PubMed / DOI ↗Angiotensin-(1-7) prevents diabetes-induced attenuation in PPAR-gamma and catalase activities.
European journal of pharmacology
PubMed / DOI ↗FPTIII mitigates peroxisome-mediated oxidative stress in kidneys of spontaneously hypertensive diabetic rats.
Kidney & blood pressure research
PubMed / DOI ↗Early inhibition of EGFR signaling prevents diabetes-induced up-regulation of multiple gene pathways in the mesenteric vasculature.
Vascular pharmacology
PubMed / DOI ↗Role of epidermal growth factor receptor (EGFR) in corneal remodelling in diabetes.
Acta ophthalmologica
PubMed / DOI ↗Global upregulation of gene expression associated with renal dysfunction in DOCA-salt-induced hypertensive rats occurs via signaling cascades involving epidermal growth factor receptor: a microarray analysis.
Vascular pharmacology
PubMed / DOI ↗Cytochrome P450 metabolites of arachidonic acid play a role in the enhanced cardiac dysfunction in diabetic rats following ischaemic reperfusion injury.
Autonomic & autacoid pharmacology
PubMed / DOI ↗Role of 20-hydroxyeicosatetraenoic acid in altering vascular reactivity in diabetes.
Autonomic & autacoid pharmacology
PubMed / DOI ↗Endogenous angiotensin-(1-7) reduces cardiac ischemia-induced dysfunction in diabetic hypertensive rats.
Pharmacological research
PubMed / DOI ↗Inhibition of Ras-GTPase signaling by FPTIII ameliorates development of cardiovascular dysfunction in diabetic-hypertensive rats.
Vascular pharmacology
PubMed / DOI ↗Role of Ca2+/calmodulin-dependent protein kinase II in development of vascular dysfunction in diabetic rats with hypertension.
Cell biochemistry and function
PubMed / DOI ↗Angiotensin-(1-7) prevents activation of NADPH oxidase and renal vascular dysfunction in diabetic hypertensive rats.
American journal of nephrology
PubMed / DOI ↗Role of cytochrome P450 metabolites of arachidonic acid in regulation of corporal smooth muscle tone in diabetic and older rats.
Vascular pharmacology
PubMed / DOI ↗Different responses to angiotensin-(1-7) in young, aged and diabetic rabbit corpus cavernosum.
Pharmacological research
PubMed / DOI ↗Toxicogenomics of drug delivery systems: Exploiting delivery system-induced changes in target gene expression to enhance siRNA activity.
Journal of drug targeting
PubMed / DOI ↗Angiotensin-(1-7) prevents diabetes-induced cardiovascular dysfunction.
American journal of physiology. Heart and circulatory physiology
PubMed / DOI ↗Cardioprotection from ischemia-reperfusion injury due to Ras-GTPase inhibition is attenuated by glibenclamide in the globally ischemic heart.
Cell biochemistry and function
PubMed / DOI ↗Angiotensin-(1-7) prevents development of severe hypertension and end-organ damage in spontaneously hypertensive rats treated with L-NAME.
American journal of physiology. Heart and circulatory physiology
PubMed / DOI ↗Phosphoinositide 3-kinase mediated signalling contributes to development of diabetes-induced abnormal vascular reactivity of rat carotid artery.
Cell biochemistry and function
PubMed / DOI ↗Contribution of cytochrome P450 metabolites of arachidonic acid to hypertension and end-organ damage in spontaneously hypertensive rats treated with L-NAME.
Autonomic & autacoid pharmacology
PubMed / DOI ↗Signal transduction involving Ras-GTPase contributes to development of hypertension and end-organ damage in spontaneously hypertensive rats-treated with L-NAME.
Pharmacological research
PubMed / DOI ↗Diabetes-induced renal vascular dysfunction is normalized by inhibition of epidermal growth factor receptor tyrosine kinase.
Journal of vascular research
PubMed / DOI ↗Inhibition of Ca2+/calmodulin-dependent protein kinase II, RAS-GTPase and 20-hydroxyeicosatetraenoic acid attenuates the development of diabetes-induced vascular dysfunction in the rat carotid artery.
Pharmacological research
PubMed / DOI ↗Epidermal growth factor receptor tyrosine kinase-mediated signalling contributes to diabetes-induced vascular dysfunction in the mesenteric bed.
British journal of pharmacology
PubMed / DOI ↗The role of tyrosine kinase-mediated pathways in diabetes-induced alterations in responsiveness of rat carotid artery.
Autonomic & autacoid pharmacology
PubMed / DOI ↗Signal transduction mechanisms involved in cardiac preconditioning: role of Ras-GTPase, Ca2+/calmodulin-dependent protein kinase II and epidermal growth factor receptor.
Molecular and cellular biochemistry
PubMed / DOI ↗Sustained polymeric delivery of gene silencing antisense ODNs, siRNA, DNAzymes and ribozymes: in vitro and in vivo studies.
Journal of drug targeting
PubMed / DOI ↗A novel anionic dendrimer for improved cellular delivery of antisense oligonucleotides.
Journal of controlled release : official journal of the Controlled Release Society
PubMed / DOI ↗Inhibition of Ras-GTPase, but not tyrosine kinases or Ca2+/calmodulin-dependent protein kinase II, improves recovery of cardiac function in the globally ischemic heart.
Molecular and cellular biochemistry
PubMed / DOI ↗Inhibition of Ras-GTPase improves diabetes-induced abnormal vascular reactivity in the rat perfused mesenteric vascular bed.
Medical principles and practice : international journal of the Kuwait University, Health Science Centre
PubMed / DOI ↗Gene silencing nucleic acids designed by scanning arrays: anti-EGFR activity of siRNA, ribozyme and DNA enzymes targeting a single hybridization-accessible region using the same delivery system.
Journal of drug targeting
PubMed / DOI ↗Toxicogenomics of non-viral vectors for gene therapy: a microarray study of lipofectin- and oligofectamine-induced gene expression changes in human epithelial cells.
Journal of drug targeting
PubMed / DOI ↗Inhibition of calcium/calmodulin-dependent protein kinase II normalizes diabetes-induced abnormal vascular reactivity in the rat perfused mesenteric vascular bed.
Autonomic & autacoid pharmacology
PubMed / DOI ↗Messenger RNA expression profiling of genes involved in epidermal growth factor receptor signalling in human cancer cells treated with scanning array-designed antisense oligonucleotides.
Biochemical pharmacology
PubMed / DOI ↗Functional significance of activation of calcium/calmodulin-dependent protein kinase II in angiotensin II--induced vascular hyperplasia and hypertension.
Hypertension (Dallas, Tex. : 1979)
PubMed / DOI ↗Angiotensin II-induced hypertension: contribution of Ras GTPase/Mitogen-activated protein kinase and cytochrome P450 metabolites.
Hypertension (Dallas, Tex. : 1979)
PubMed / DOI ↗Ras/mitogen-activated protein kinase mediates norepinephrine-induced phospholipase D activation in rabbit aortic smooth muscle cells by a phosphorylation-dependent mechanism.
The Journal of pharmacology and experimental therapeutics
PubMed / DOI ↗Contribution of Ras GTPase/MAP kinase and cytochrome P450 metabolites to deoxycorticosterone-salt-induced hypertension.
Hypertension (Dallas, Tex. : 1979)
PubMed / DOI ↗20-Hydroxyeicosatetraenoic acid mediates calcium/calmodulin-dependent protein kinase II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells.
Proceedings of the National Academy of Sciences of the United States of America
PubMed / DOI ↗How selective is 7-nitroindazole, an inhibitor of neuronal nitric oxide synthase?
Anesthesia and analgesia
PubMed / DOI ↗Central nervous system is not involved in initiation of the pressor effect of 7-nitroindazole in urethane-anesthetized rats.
Hypertension (Dallas, Tex. : 1979)
PubMed / DOI ↗Cytochrome P-450 metabolites mediate norepinephrine-induced mitogenic signaling.
Hypertension (Dallas, Tex. : 1979)
PubMed / DOI ↗Signal transduction mechanisms involved in angiotensin-(1-7)-stimulated arachidonic acid release and prostanoid synthesis in rabbit aortic smooth muscle cells.
The Journal of pharmacology and experimental therapeutics
PubMed / DOI ↗Acute depressor actions of angiotensin II in the nucleus of the solitary tract are mediated by substance P.
The American journal of physiology
PubMed / DOI ↗Calcium/calmodulin-dependent protein kinase IIalpha mediates activation of mitogen-activated protein kinase and cytosolic phospholipase A2 in norepinephrine-induced arachidonic acid release in rabbit aortic smooth muscle cells.
The Journal of biological chemistry
PubMed / DOI ↗Pressor and reflex sensitivity is altered in spontaneously hypertensive rats treated with angiotensin-(1-7).
Hypertension (Dallas, Tex. : 1979)
PubMed / DOI ↗Antihypertensive actions of angiotensin-(1-7) in spontaneously hypertensive rats.
The American journal of physiology
PubMed / DOI ↗Differential processing of substance P and neurokinin A by plasma dipeptidyl(amino)peptidase IV, aminopeptidase M and angiotensin converting enzyme.
Peptides
PubMed / DOI ↗N-terminal degradation of low molecular weight opioid peptides in human cerebrospinal fluid.
Biochemical pharmacology
PubMed / DOI ↗Enalapril prevents stroke and kidney dysfunction in salt-loaded stroke-prone spontaneously hypertensive rats.
Hypertension (Dallas, Tex. : 1979)
PubMed / DOI ↗Thromboxane A2 in severe hypertension and stroke in stroke-prone spontaneously hypertensive rats.
Stroke
PubMed / DOI ↗